The movie opens at Azim’s (Mina E. Mina) barber shop, where he and his nephew Ekrem (Josef Altin) murder a Russian mafia gangster who is getting his hair cut.
Anna Khitrova (Naomi Watts), a midwife at a London hospital, delivers a baby girl from an unconscious and hemorrhaging fourteen-year-old. The teenager dies during childbirth and has no identification other than a diary, written in Russian, and a business card for a restaurant named Trans-Siberian. Later, Anna and her mother Helen (Sinéad Cusack) are visited by her Russian-born Uncle Stepan (Jerzy Skolimowski), who refuses to translate the diary and urges her to destroy it and not get involved.
Wanting to find relatives for the new-born girl, Anna sets out to uncover the mother’s identity. She visits the Trans-Siberian, owned by Semyon (Armin Mueller-Stahl), who offers to translate the dead girl’s diary for her. But unknown to Anna, Semyon is a boss in the Russian Mafia or vor v zakone (“thief in law“). Outside the Trans-Siberian Anna meets Nikolai Luzhin (Viggo Mortensen), the chauffeur and assistant of Semyon’s unstable son, Kirill (Vincent Cassel), a violent and abusive drunk.
Above Azim’s barber shop Nikolai and Kirill relieve Azim of the body of the murdered Russian gangster. It turns out that Kirill ordered the ill-advised murder. Nikolai helps make the body difficult to identify by removing the teeth and cutting off the finger tips. Nikolai and Kirill then dispose of the body by throwing it into the River Thames from the end of a narrow alley.
Anna returns to the Trans-Siberian the next day with photocopies of the diary pages. Semyon asks where the original is, and where Anna lives, but Anna is sufficiently careful to refuse to reply, saying she’ll return in a couple of days for the translation. But Semyon has learned where Anna works, and shows up at the hospital. He admits that the diary contains compromising information about his son Kirill, and offers to provide Anna with the address of the baby’s mother’s family in exchange for the original diary, while subtly threatening to harm the baby if Anna does not cooperate.
Uncle Stepan grudgingly agrees to translate the diary after all. Anna learns that the girl had been lured to London with promises of a well-paid job as a singer, and then forced into prostitution. To “break her in” Semyon had raped the girl, after which she was kept in a state of heroin dependency and also fed P-pills. From this information Anna deduces that Semyon must be the father of the baby girl.
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